Laboratory of Neuro Imaging Resource
From BTRR
Overview
The Laboratory of Neuro Imaging Resource (LONIR) develops novel strategies to investigate brain structure and function in their full multidimensional complexity. There is a rapidly growing need for brain models comprehensive enough to represent brain structure and function as they change across time in large populations, in different disease states, across imaging modalities, across age and sex, and even across species. International networks of collaborators are provided with a diverse array of tools to create, analyze, visualize, and interact with models of the brain. A major focus of these collaborations is to develop four-dimensional brain models that track and analyze complex patterns of dynamically changing brain structure in development and disease, expanding investigations of brain structure-function relations to four dimensions.
Current Research
The development of modeling approaches focuses on new strategies for surface and volume parameterization that provide an advanced analysis of surface and volumetric brain models, tracking their change across time. Additional research cores focus on anatomic fundamentals, analyzing anatomic and cytoarchitectural attributes across multiple scales and across time. Another core focuses on visualization and animation, for the dissemination of brain models that visualize complex variations in brain structure and function across time. Specialized approaches are under development for handling cortical data. Ongoing national and international collaborations are analyzing normal and aberrant growth processes, brain development, tumor growth, Alzheimer's disease and related degenerative disease processes, schizophrenia, and brain structure in normal and diseased twins.
