National Resource for Automated Molecular Microscopy
From BTRR
Overview
The overall mission of the National Resource for Automated Molecular Microscopy is to develop, test, and apply technology aimed toward completely automating the processes involved in solving macromolecular structures using cryoelectron microscopy (cryoEM). The goal is to establish a resource that will serve both as a center for high-throughput molecular microscopy as well as for transferring this technique to the research community.
Core technology development projects include the following:
Specimen handling: Projects in this core are all related to improving the handling and monitoring of specimens by developing innovative new engineering devices. These include developing methods for high throughput screening of negatively stained ordered arrays and controlling the stability of cryostage specimen holders.
Automated acquisition: The fundamental core technology of the resource is the development of a generalized system for automated image acquisition.
Automated processing: The focus of this core is the automation of the data processing that follows image acquisition. A particular emphasis is the automated identification and segmentation of individual structures from electron micrographs.
Information handling: The storage, organization, distribution, and archiving of information is the focus of this core project.
