Proteomics Research for Integrative Biology
From BTRR
Overview
This resource focuses on assisting biomedical researchers through the development and application of advanced proteomics technologies designed for the characterization of biomedically important systems, including pathogenic microbes, viruses, animal models, human tissues, biofluids, cultured cell lines, and clinically obtained samples. Unique capabilities include nanoscale sample handling combined with high-throughput, high-pressure, high-resolution capillary liquid chromatography (LC) coupled to electrospray ionization interfaced high-sensitivity, wide-dynamic-range Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS).
Current Research
Development and application of new MS instrumentation and online and offline LC separation methods for the characterization of highly complex proteomic systems, including peptide and protein identification, and quantitation methods; characterization methods implement bottom-up and top-down approaches to facilitate identification of protein posttranslational modifications. Development of new informatics software tools to facilitate the quantitation, validation, and interpretation of proteomic data.
