Resource for Biocomputing, Visualization, and Informatics
From BTRR
Overview
The Resource for Biocomputing, Visualization, and Informatics creates innovative computational and visualization-based data analysis methods and algorithms; implements these as professional-quality, fully documented, easy-to-use software tools; and applies these tools to solve a wide range of genomic and molecular recognition problems within the complex sequence-structure-function triad. Application areas include gene characterization and interpretation, drug design, variation in drug response due to genetic factors, protein engineering, biomaterials design, and prediction of function from sequence and structure.
Current Research
Sequence analysis and bioinformatics: The characterization and interpretation of genomic data, including knowledge discovery and transfer in nucleic acid and protein sequence analysis, pharmacogenomics, and the identification of gene and regulatory motifs, protein family/superfamily relationships, and gene expression patterns.
Structural informatics: The development, application, and dissemination of analysis methodologies and software tools in computational structural biology, including algorithm development of low- and high-resolution protein structural models and their comparison, molecular visualization for structural analysis and the integration of sequence and tertiary structural information, and facilitation of collaborative research through use of high-performance network technology.
Functional informatics: Theoretical and applied research in how protein structures deliver function, including the identification and characterization of protein superfamilies, the generation of new computational-based representations of protein chemistry, and the development of structurally contextual definitions of protein function.
